Insertions and deletions trigger adaptive walks in Drosophila proteins

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Leushkin, Evgeny V.; Bazykin, Georgii A.; Kondrashov, Alexey S.; (2012)
  • Publisher: The Royal Society
  • Journal: Proceedings of the Royal Society B: Biological Sciences,volume 279,issue 1,740,pages3,075-3,082 (issn: 0962-8452, eissn: 1471-2954)
  • Related identifiers: doi: 10.1098/rspb.2011.2571, pmc: PMC3385466
  • Subject: indels | 1001 | adaptive walk | 70 | fitness landscape | Research Articles | McDonald–Kreitman
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Maps that relate all possible genotypes or phenotypes to fitness—fitness landscapes—are central to the evolution of life, but remain poorly known. An insertion or a deletion (indel) of one or several amino acids constitutes a substantial leap of a protein within the spa... View more
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