publication . Preprint . Article . Other literature type . 2017

Systematic integration of biomedical knowledge prioritizes drugs for repurposing.

Himmelstein, Daniel S.; Lizee, Antoine; Hessler, Christine; Brueggeman, Leo; Chen, Sabrina L.; Hadley, Dexter; Green, Ari; Khankhanian, Pouya; Baranzini, Sergio E.;
Open Access
  • Published: 22 Sep 2017
  • Publisher: Cold Spring Harbor Laboratory
Abstract
[u'Of all the data in the world today, 90% was created in the last two years. However, taking advantage of this data in order to advance our knowledge is restricted by how quickly we can access it and analyze it in a proper context.', u'In biomedical research, data is largely fragmented and stored in databases that typically do not \u201ctalk\u201d to each other, thus hampering progress. One particular problem in medicine today is that the process of making a new therapeutic drug from scratch is incredibly expensive and inefficient, making it a risky business. Given the low success rate in drug discovery, there is an economic incentive in trying to repurpose an ...
Subjects
free text keywords: Humans, Computational Biology, Systems Biology, Models, Biological, Drug Discovery, drug repurposing, heterogeneous networks, human, machine learning, Biochemistry and Cell Biology, Disease, Drug repositioning, Biology, Bioinformatics, Repurposing, Drug approval, Incentive, Drug, media_common.quotation_subject, media_common, Data science, Genetics, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Research Article, Computational and Systems Biology
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NIH| Crowd-sourcing A STAR Functional Genomic Characterization of Cancer with Open Big Data
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  • Funder: National Institutes of Health (NIH)
  • Project Code: 1UH2CA203792-01
  • Funding stream: NATIONAL CANCER INSTITUTE
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NIH| Post GWAS approach to identify cell-specific genetic pathways underlying MS risk
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  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01NS088155-03
  • Funding stream: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
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NIH| Crowd-Assisted Deep Learning (CrADLe) Digital Curation to Translate Big Data into Precision Medicine
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  • Funder: National Institutes of Health (NIH)
  • Project Code: 1U01LM012675-01
  • Funding stream: NATIONAL LIBRARY OF MEDICINE
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NSF| Graduate Research Fellowship Program (GRFP)
Project
  • Funder: National Science Foundation (NSF)
  • Project Code: 1144247
  • Funding stream: Directorate for Education & Human Resources | Division of Graduate Education
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publication . Preprint . Article . Other literature type . 2017

Systematic integration of biomedical knowledge prioritizes drugs for repurposing.

Himmelstein, Daniel S.; Lizee, Antoine; Hessler, Christine; Brueggeman, Leo; Chen, Sabrina L.; Hadley, Dexter; Green, Ari; Khankhanian, Pouya; Baranzini, Sergio E.;