publication . Article . Other literature type . 2005

Hedgehog Antagonist RENKCTD11 Regulates Proliferation and Apoptosis of Developing Granule Cell Progenitors

Sonia Canterini;
Open Access
  • Published: 07 Sep 2005 Journal: Journal of Neuroscience, volume 25, pages 8,338-8,346 (issn: 0270-6474, eissn: 1529-2401, Copyright policy)
  • Publisher: Society for Neuroscience
Abstract
During the early development of the cerebellum, a burst of granule cell progenitor (GCP) proliferation occurs in the outer external granule layer (EGL), which is sustained mainly by Purkinje cell-derived Sonic Hedgehog (Shh). Shh response is interrupted once GCPs move into the inner EGL, where granule progenitors withdraw proliferation and start differentiating and migrating toward the internal granule layer (IGL). Failure to interrupt Shh signals results in uncoordinated proliferation and differentiation of GCPs and eventually leads to malignancy (i.e., medulloblastoma). The Shh inhibitory mechanisms that are responsible for GCP growth arrest and differentiatio...
Subjects
Medical Subject Headings: animal structuresembryonic structures
free text keywords: General Neuroscience, Downregulation and upregulation, Hedgehog signaling pathway, Progenitor, Progenitor cell, Sonic hedgehog, biology.protein, biology, Granule cell, medicine.anatomical_structure, medicine, GLI1, Hedgehog, Anatomy, Development/Plasticity/Repair
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publication . Article . Other literature type . 2005

Hedgehog Antagonist RENKCTD11 Regulates Proliferation and Apoptosis of Developing Granule Cell Progenitors

Sonia Canterini;