Pharmacokinetics of cefotaxime and desacetylcefotaxime in patients with liver disease.

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Ko, R J; Sattler, F R; Nichols, S; Akriviadis, E; Runyon, B; Appleman, M; Cohen, J L; Koda, R T;

The dispositions of cefotaxime and its metabolite desacetylcefotaxime were investigated in patients with different forms of chronic parenchymal liver disease (CPLD). A total of 31 subjects (27 patients and 4 controls) received a single 2-g dose of cefotaxime by infusion... View more
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