publication . Article . Other literature type . 2013

STAT4 is a genetic risk factor for systemic sclerosis in a Chinese population.

Yi, L.; Wang, J.C.; Guo, X.J.; Gu, Y.H.; Tu, W.Z.; Guo, G.; Yang, L.; Xiao, R.; Yu, L.; Mayes, M.D.; ...
Open Access
  • Published: 01 Apr 2013 Journal: International Journal of Immunopathology and Pharmacology, volume 26, pages 473-478 (issn: 0394-6320, Copyright policy)
  • Publisher: SAGE Publications
Abstract
Systemic sclerosis (SSc) is an immune-mediated and complex genetic disease. An association of single-nucleotide polymorphisms (SNPs) in the STAT4 gene with SSc has been reported in European Caucasians, North Americans and Japanese. We undertook the current study to examine whether the STAT4 SNPs are also associated with susceptibility to SSc and SSc subsets in a Han Chinese population. A total of 453 Han Chinese patients with SSc and 534 healthy controls were examined in the study. The SNPs rs7574865, rs10168266 and rs3821236 of the STAT4 gene were examined with SNP TaqMan assays. The T-allele carriers of rs7574865 and rs10168266 were strongly associated with th...
Subjects
Medical Subject Headings: skin and connective tissue diseasesintegumentary system
free text keywords: Immunology, Polymorphism (computer science), Autoantibody, Single-nucleotide polymorphism, Case-control study, STAT4, Odds ratio, Medicine, business.industry, business, Population, education.field_of_study, education, Disease, Article
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publication . Article . Other literature type . 2013

STAT4 is a genetic risk factor for systemic sclerosis in a Chinese population.

Yi, L.; Wang, J.C.; Guo, X.J.; Gu, Y.H.; Tu, W.Z.; Guo, G.; Yang, L.; Xiao, R.; Yu, L.; Mayes, M.D.; ...