publication . Other literature type . 2018

Timing of Prenatal Exposure to Trauma and Altered Placental Expressions of HPA-Axis Genes and Genes Driving Neurodevelopment

Zhang, Wei; Li, Qian; Deyssenroth, Maya; Lambertini, Luca; Finik, Jackie; Ham, Jacob; Huang, Yongling; Tsuchiya, Kenji J; Pehme, Patricia; Buthmann, Jessica; ...
Open Access English
  • Published: 01 Apr 2018
Abstract
Prenatal maternal stress increases the risk for negative developmental outcomes in offspring, however the underlying biological mechanisms remain largely unexplored. In this study, alterations in placental gene expression associated with maternal stress were examined to elucidate potential underlying epi/genetic mechanisms. Expression levels of 40 selected genes involved in regulating fetal HPA-axis and neurodevelopment were profiled in placental tissues collected from a birth cohort established around the time of Superstorm Sandy. Objective prenatal traumatic stress was defined as whether mothers were exposed to Superstorm Sandy during pregnancy. Among the 275 ...
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Other literature type . 2018
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