publication . Article . Other literature type . 2001

Link of the unique oncogenic properties of adenovirus type 9 E4‐ORF1 to a select interaction with the candidate tumor suppressor protein ZO‐2

Glaunsinger, Britt A.; Weiss, Robert S.; Lee, Siu Sylvia; Javier, Ronald;
Open Access
  • Published: 15 Oct 2001 Journal: The EMBO Journal, volume 20, pages 5,578-5,586 (eissn: 1460-2075, Copyright policy)
  • Publisher: Wiley
Abstract
Adenovirus type 9 (Ad9) is distinct among human adenoviruses because it elicits solely mammary tumors in animals and its primary oncogenic determinant is the E4 region-encoded ORF1 (E4-ORF1) protein. We report here that the PDZ domain-containing protein ZO-2, which is a candidate tumor suppressor protein, is a cellular target for tumorigenic Ad9 E4-ORF1 but not for non-tumorigenic wild-type E4-ORF1 proteins encoded by adenovirus types 5 and 12. Complex formation was mediated by the C-terminal PDZ domain-binding motif of Ad9 E4- ORF1 and the first PDZ domain of ZO-2, and in cells this interaction resulted in aberrant sequestration of ZO-2 within the cytoplasm. Fu...
Subjects
Medical Subject Headings: virusesbiochemical phenomena, metabolism, and nutritionbacteria
free text keywords: Retinoblastoma-like protein 1, Human Adenoviruses, Genetics, Candidate Tumor Suppressor Protein, Cytoplasm, Molecular biology, PDZ domain, Biology, Mutant, Article
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publication . Article . Other literature type . 2001

Link of the unique oncogenic properties of adenovirus type 9 E4‐ORF1 to a select interaction with the candidate tumor suppressor protein ZO‐2

Glaunsinger, Britt A.; Weiss, Robert S.; Lee, Siu Sylvia; Javier, Ronald;