Recipient-type specific CD4+CD25+ regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemia

Other literature type English OPEN
Trenado, Aurélie; Charlotte, Frédéric; Fisson, Sylvain; Yagello, Micael; Klatzmann, David; Salomon, Benoît L.; Cohen, José L.;
  • Publisher: American Society for Clinical Investigation
  • Related identifiers: doi: 10.1172/JCI200317702, pmc: PMC281639
  • Subject: Article
    mesheuropmc: surgical procedures, operative | chemical and pharmacologic phenomena

CD4+CD25+ regulatory T cells (Treg’s) play a pivotal role in preventing organ-specific autoimmune diseases and in inducing tolerance to allogeneic organ transplants. We and others recently demonstrated that high numbers of Treg’s can also modulate graft-versus-host dise... View more
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