publication . Article . 2018

N-Terminal Extension and C-Terminal Domains Are Required for ABCB6/HMT-1 Protein Interactions, Function in Cadmium Detoxification, and Localization to the Endosomal-Recycling System in Caenorhabditis elegans

Anuj Sharma;
Open Access English
  • Published: 30 Jul 2018 Journal: Frontiers in Physiology (issn: 1664-042X, Copyright policy)
  • Publisher: Frontiers Media S.A.
Abstract
The chronic exposure of humans to toxic metals such as cadmium from food and air causes dysfunction of vital organs, neurodegenerative conditions, and cancer. In this regard, members of the ABCB sub-family of the ATP-binding cassette (ABC) transporter superfamily, ABCB6/HMT-1, are acutely required for the detoxification of heavy metals and are present in genomes of many organisms including the nematode worm, Caenorhabditis elegans and humans. We showed previously that C. elegans ABCB6/HMT-1 detoxifies cadmium, copper, and arsenic, and is expressed in liver-like cells, the coelomocytes, head neurons and intestinal cells, which are the cell types that are affected...
Subjects
free text keywords: heavy metals, cadmium, HMT-1, ABCB6, ABC transporters, recycling endosomes, Physiology, QP1-981, Original Research, C. elegans, Physiology (medical), Caenorhabditis elegans, biology.organism_classification, biology, Internal medicine, medicine.medical_specialty, medicine, Metal poisoning, Transmembrane protein, Cell biology, ATP-binding cassette transporter, Endosome, Subcellular localization, Transmembrane domain, Protein–protein interaction, Endocrinology
Related Organizations
Funded by
NSF| Biochemical and Molecular Genetic Studies of the HMT-1-Dependent Heavy Metal Detoxification Pathway in C. Elegans
Project
  • Funder: National Science Foundation (NSF)
  • Project Code: 0923731
  • Funding stream: Directorate for Biological Sciences | Division of Molecular & Cellular Biosciences
,
NIH| Caenorhabditis Genetics Center
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1P40OD010440-01
  • Funding stream: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH
65 references, page 1 of 5

Baron S.Carignan J.Ploquin A. (2006). Dispersion of heavy metals (metalloids) in soils from 800-year-old pollution (Mont-Lozere, France). Environ. Sci. Technol. 40 5319–5326. 10.1021/es0606430 16999105 [OpenAIRE] [PubMed] [DOI]

Beis K. (2015). Structural basis for the mechanism of ABC transporters. Biochem. Soc. Trans. 43 889–893. 10.1042/BST20150047 26517899 [OpenAIRE] [PubMed] [DOI]

Bhuiyan M. S. U.Min S. R.Jeong W. J.Sultana S.Choi K. S.Song W. Y. (2011). Overexpression of a yeast cadmium factor 1 (YCF1) enhances heavy metal tolerance and accumulation in Brassica juncea. Plant Cell Tissue Organ Cult. 105 85–91. 10.1007/s11240-010-9845-y [OpenAIRE] [DOI]

Blaby-Haas C. E.Merchant S. S. (2014). Lysosome-related organelles as mediators of metal homeostasis. J. Biol. Chem. 289 28129–28136. 10.1074/jbc.R114.592618 25160625 [OpenAIRE] [PubMed] [DOI]

Boswell-Casteel R. C.Fukuda Y.Schuetz J. D. (2017). ABCB6, an ABC transporter impacting drug response and disease. AAPS J. 20:8. 10.1208/s12248-017-0165-6 29192381 [OpenAIRE] [PubMed] [DOI]

Brenner S. (1974). The genetics of Caenorhabditis elegans. Genetics 77 71–94.4366476 [OpenAIRE] [PubMed]

Broeks A.Gerrard B.Allikmets R.Dean M.Plasterk R. H. (1996). Homologues of the human multidrug resistance genes MRP and MDR contribute to heavy metal resistance in the soil nematode Caenorhabditis elegans. EMBO J. 15 6132–6143. 8947035 [OpenAIRE] [PubMed]

Campbell R. E.Tour O.Palmer A. E.Steinbach P. A.Baird G. S. (2002). A monomeric red fluorescent protein. Proc. Natl. Acad. Sci. U.S.A. 99 7877–7882. 10.1073/pnas.082243699 12060735 [OpenAIRE] [PubMed] [DOI]

Dean M.Hamon Y.Chimini G. (2001a). The human ATP-binding cassette (ABC) transporter superfamily. J. Lipid Res. 42 1007–1017. 10.1101/gr.GR-1649R 11441126 [OpenAIRE] [PubMed] [DOI]

Dean M.Rzhetsky A.Allikmets R. (2001b). The human ATP-binding cassette (ABC) transporter superfamily. Genome Res. 11 1156–1166. 10.1101/gr.GR-1649R 11435397 [PubMed] [DOI]

Eide D.Broderius M.Fett J.Guerinot M. L. (1996). A novel iron-regulated metal transporter from plants identified by functional expression in yeast. Proc. Natl. Acad. Sci. U.S.A. 93 5624–5628. 10.1073/pnas.93.11.5624 8643627 [OpenAIRE] [PubMed] [DOI]

Emadi-Konjin H. P.Zhang H.Anandan V.Sun D.Schuetz J.Furuya K. N. (2002). Isolation of a genomic clone containing the promoter region of the human ATP binding cassette (ABC) transporter, ABCB6. Biochim. Biophys. Acta 1574 117–130. 10.1016/S0167-4781(01)00340-2 11955620 [OpenAIRE] [PubMed] [DOI]

Fire A.Kondo K.Waterston R. (1990). Vectors for low copy transformation of C. elegans. Nucleic Acids Res. 18 4269–4270. 10.1093/nar/18.14.4269 2377476 [OpenAIRE] [PubMed] [DOI]

Goldenring J. R. (2015). Recycling endosomes. Curr. Opin. Cell Biol. 35 117–122. 10.1016/j.ceb.2015.04.018 26022676 [OpenAIRE] [PubMed] [DOI]

Hanikenne M.Kramer U.Demoulin V.Baurain D. (2005). A comparative inventory of metal transporters in the green alga Chlamydomonas reinhardtii and the red alga Cyanidioschizon merolae. Plant Physiol. 137 428–446. 10.1104/pp.104.054189 15710683 [OpenAIRE] [PubMed] [DOI]

65 references, page 1 of 5
Related research
Abstract
The chronic exposure of humans to toxic metals such as cadmium from food and air causes dysfunction of vital organs, neurodegenerative conditions, and cancer. In this regard, members of the ABCB sub-family of the ATP-binding cassette (ABC) transporter superfamily, ABCB6/HMT-1, are acutely required for the detoxification of heavy metals and are present in genomes of many organisms including the nematode worm, Caenorhabditis elegans and humans. We showed previously that C. elegans ABCB6/HMT-1 detoxifies cadmium, copper, and arsenic, and is expressed in liver-like cells, the coelomocytes, head neurons and intestinal cells, which are the cell types that are affected...
Subjects
free text keywords: heavy metals, cadmium, HMT-1, ABCB6, ABC transporters, recycling endosomes, Physiology, QP1-981, Original Research, C. elegans, Physiology (medical), Caenorhabditis elegans, biology.organism_classification, biology, Internal medicine, medicine.medical_specialty, medicine, Metal poisoning, Transmembrane protein, Cell biology, ATP-binding cassette transporter, Endosome, Subcellular localization, Transmembrane domain, Protein–protein interaction, Endocrinology
Related Organizations
Funded by
NSF| Biochemical and Molecular Genetic Studies of the HMT-1-Dependent Heavy Metal Detoxification Pathway in C. Elegans
Project
  • Funder: National Science Foundation (NSF)
  • Project Code: 0923731
  • Funding stream: Directorate for Biological Sciences | Division of Molecular & Cellular Biosciences
,
NIH| Caenorhabditis Genetics Center
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1P40OD010440-01
  • Funding stream: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH
65 references, page 1 of 5

Baron S.Carignan J.Ploquin A. (2006). Dispersion of heavy metals (metalloids) in soils from 800-year-old pollution (Mont-Lozere, France). Environ. Sci. Technol. 40 5319–5326. 10.1021/es0606430 16999105 [OpenAIRE] [PubMed] [DOI]

Beis K. (2015). Structural basis for the mechanism of ABC transporters. Biochem. Soc. Trans. 43 889–893. 10.1042/BST20150047 26517899 [OpenAIRE] [PubMed] [DOI]

Bhuiyan M. S. U.Min S. R.Jeong W. J.Sultana S.Choi K. S.Song W. Y. (2011). Overexpression of a yeast cadmium factor 1 (YCF1) enhances heavy metal tolerance and accumulation in Brassica juncea. Plant Cell Tissue Organ Cult. 105 85–91. 10.1007/s11240-010-9845-y [OpenAIRE] [DOI]

Blaby-Haas C. E.Merchant S. S. (2014). Lysosome-related organelles as mediators of metal homeostasis. J. Biol. Chem. 289 28129–28136. 10.1074/jbc.R114.592618 25160625 [OpenAIRE] [PubMed] [DOI]

Boswell-Casteel R. C.Fukuda Y.Schuetz J. D. (2017). ABCB6, an ABC transporter impacting drug response and disease. AAPS J. 20:8. 10.1208/s12248-017-0165-6 29192381 [OpenAIRE] [PubMed] [DOI]

Brenner S. (1974). The genetics of Caenorhabditis elegans. Genetics 77 71–94.4366476 [OpenAIRE] [PubMed]

Broeks A.Gerrard B.Allikmets R.Dean M.Plasterk R. H. (1996). Homologues of the human multidrug resistance genes MRP and MDR contribute to heavy metal resistance in the soil nematode Caenorhabditis elegans. EMBO J. 15 6132–6143. 8947035 [OpenAIRE] [PubMed]

Campbell R. E.Tour O.Palmer A. E.Steinbach P. A.Baird G. S. (2002). A monomeric red fluorescent protein. Proc. Natl. Acad. Sci. U.S.A. 99 7877–7882. 10.1073/pnas.082243699 12060735 [OpenAIRE] [PubMed] [DOI]

Dean M.Hamon Y.Chimini G. (2001a). The human ATP-binding cassette (ABC) transporter superfamily. J. Lipid Res. 42 1007–1017. 10.1101/gr.GR-1649R 11441126 [OpenAIRE] [PubMed] [DOI]

Dean M.Rzhetsky A.Allikmets R. (2001b). The human ATP-binding cassette (ABC) transporter superfamily. Genome Res. 11 1156–1166. 10.1101/gr.GR-1649R 11435397 [PubMed] [DOI]

Eide D.Broderius M.Fett J.Guerinot M. L. (1996). A novel iron-regulated metal transporter from plants identified by functional expression in yeast. Proc. Natl. Acad. Sci. U.S.A. 93 5624–5628. 10.1073/pnas.93.11.5624 8643627 [OpenAIRE] [PubMed] [DOI]

Emadi-Konjin H. P.Zhang H.Anandan V.Sun D.Schuetz J.Furuya K. N. (2002). Isolation of a genomic clone containing the promoter region of the human ATP binding cassette (ABC) transporter, ABCB6. Biochim. Biophys. Acta 1574 117–130. 10.1016/S0167-4781(01)00340-2 11955620 [OpenAIRE] [PubMed] [DOI]

Fire A.Kondo K.Waterston R. (1990). Vectors for low copy transformation of C. elegans. Nucleic Acids Res. 18 4269–4270. 10.1093/nar/18.14.4269 2377476 [OpenAIRE] [PubMed] [DOI]

Goldenring J. R. (2015). Recycling endosomes. Curr. Opin. Cell Biol. 35 117–122. 10.1016/j.ceb.2015.04.018 26022676 [OpenAIRE] [PubMed] [DOI]

Hanikenne M.Kramer U.Demoulin V.Baurain D. (2005). A comparative inventory of metal transporters in the green alga Chlamydomonas reinhardtii and the red alga Cyanidioschizon merolae. Plant Physiol. 137 428–446. 10.1104/pp.104.054189 15710683 [OpenAIRE] [PubMed] [DOI]

65 references, page 1 of 5
Related research
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