Assessing the Essentiality of Leishmania donovani Nitroreductase and Its Role in Nitro Drug Activation

Other literature type English OPEN
Wyllie, Susan; Patterson, Stephen; Fairlamb, Alan H.;

The nitroimidazole fexinidazole has potential as a safe and effective oral drug therapy for the treatment of visceral leishmaniasis. To date, nitroheterocyclics have not been used in the treatment of leishmaniasis, and relatively little is known about their mechanism of... View more
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