publication . Article . Other literature type . 2015

Deletion ofliaRReverses Daptomycin Resistance in Enterococcus faecium Independent of the Genetic Background

Yousif Shamoo;
Open Access
  • Published: 14 Sep 2015 Journal: Antimicrobial Agents and Chemotherapy, volume 59, pages 7,327-7,334 (issn: 0066-4804, eissn: 1098-6596, Copyright policy)
  • Publisher: American Society for Microbiology
Abstract
<jats:title>ABSTRACT</jats:title><jats:p>We have shown previously that changes in LiaFSR, a three-component regulatory system predicted to orchestrate the cell membrane stress response, are important mediators of daptomycin (DAP) resistance in enterococci. Indeed, deletion of the gene encoding the response regulator LiaR in a clinical strain of<jats:named-content xmlns:xlink="http://www.w3.org/1999/xlink" content-type="genus-species" xlink:type="simple">Enterococcus faecalis</jats:named-content>reversed DAP resistance (DAP-R) and produced a strain hypersusceptible to antimicrobial peptides. Since LiaFSR is conserved in<jats:named-content xmlns:xlink="http://www....
Subjects
free text keywords: Pharmacology (medical), Pharmacology, Infectious Diseases, Response regulator, Enterococcus faecium, biology.organism_classification, biology, Antimicrobial peptides, Microbiology, Bacteria, Daptomycin, medicine.drug, medicine, Mutant, Enterococcus faecalis, Strain (chemistry), Mechanisms of Resistance
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publication . Article . Other literature type . 2015

Deletion ofliaRReverses Daptomycin Resistance in Enterococcus faecium Independent of the Genetic Background

Yousif Shamoo;