publication . Article . Other literature type . 2013

Aldose reductase regulates acrolein-induced cytotoxicity in human small airway epithelial cells

Yadav, Umesh C.S.; Ramana, K.V.; Srivastava, Satish K.;
Open Access
  • Published: 12 Jun 2013 Journal: Free Radical Biology and Medicine, volume 65, pages 15-25 (issn: 0891-5849, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Abstract Aldose reductase (AR), a glucose-metabolizing enzyme, reduces lipid aldehydes and their glutathione conjugates with more than 1000-fold efficiency (Km aldehydes 5–30 µM) relative to glucose. Acrolein, a major endogenous lipid peroxidation product as well as a component of environmental pollutants and cigarette smoke, is known to be involved in various pathologies including atherosclerosis, airway inflammation, COPD, and age-related disorders, but the mechanism of acrolein-induced cytotoxicity is not clearly understood. We have investigated the role of AR in acrolein-induced cytotoxicity in primary human small airway epithelial cells (SAECs). Exposure of...
Subjects
free text keywords: Physiology (medical), Biochemistry, Apoptosis, Chemistry, Kinase, Programmed cell death, Annexin, Aldose reductase, Fidarestat, Protein kinase A, Acrolein, chemistry.chemical_compound, Article
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publication . Article . Other literature type . 2013

Aldose reductase regulates acrolein-induced cytotoxicity in human small airway epithelial cells

Yadav, Umesh C.S.; Ramana, K.V.; Srivastava, Satish K.;