Evaluation of the Efficacy of ChAd63-MVA Vectored Vaccines Expressing Circumsporozoite Protein and ME-TRAP Against Controlled Human Malaria Infection in Malaria-Naive Individuals

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Hodgson, Susanne H. ; Ewer, Katie J. ; Bliss, Carly M. ; Edwards, Nick J. ; Rampling, Thomas ; Anagnostou, Nicholas A. ; de Barra, Eoghan ; Havelock, Tom ; Bowyer, Georgina ; Poulton, Ian D. ; de Cassan, Simone ; Longley, Rhea ; Illingworth, Joseph J. ; Douglas, Alexander D. ; Mange, Pooja B. ; Collins, Katharine A. ; Roberts, Rachel ; Gerry, Stephen ; Berrie, Eleanor ; Moyle, Sarah ; Colloca, Stefano ; Cortese, Riccardo ; Sinden, Robert E. ; Gilbert, Sarah C. ; Bejon, Philip ; Lawrie, Alison M. ; Nicosia, Alfredo ; Faust, Saul N. ; Hill, Adrian V. S. (2014)
  • Publisher: Oxford University Press
  • Journal: The Journal of Infectious Diseases, volume 211, issue 7, pages 1,076-1,086 (issn: 0022-1899, eissn: 1537-6613)
  • Related identifiers: doi: 10.1093/infdis/jiu579, pmc: PMC4354983
  • Subject: CS | vaccine | ChAd63 | ME-TRAP | P. falciparum | Parasites | MVA | malaria | Major Articles and Brief Reports | CHMI
    mesheuropmc: complex mixtures | viruses

Background. Circumsporozoite protein (CS) is the antigenic target for RTS,S, the most advanced malaria vaccine to date. Heterologous prime-boost with the viral vectors simian adenovirus 63 (ChAd63)-modified vaccinia virus Ankara (MVA) is the most potent inducer of T-cel... View more
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