Setd1a regulates progenitor B-cell-to-precursor B-cell development through histone H3 lysine 4 trimethylation and Ig heavy-chain rearrangement

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Tusi, Betsabeh Khoramian; Deng, Changwang; Salz, Tal; Zeumer, Leilani; Li, Yangqiu; So, Chi Wai Eric; Morel, Laurence M.; Qiu, Yi; Huang, Suming;

SETD1A is a member of trithorax-related histone methyltransferases that methylate lysine 4 at histone H3 (H3K4). We showed previously that Setd1a is required for mesoderm specification and hematopoietic lineage differentiation in vitro. However, it remains unknown wheth... View more
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