publication . Article . Other literature type . 2002

Fission Yeast F-box Protein Pof3 Is Required for Genome Integrity and Telomere Function

Katayama, Satoshi; Kitamura, Kenji; Lehmann, Anna; Nikaido, Osamu; Toda, Takashi;
Open Access
  • Published: 01 Jan 2002 Journal: Molecular Biology of the Cell, volume 13, pages 211-224 (issn: 1059-1524, eissn: 1939-4586, Copyright policy)
  • Publisher: American Society for Cell Biology (ASCB)
Abstract
<jats:p> The Skp1-Cullin-1/Cdc53-F-box protein (SCF) ubiquitin ligase plays an important role in various biological processes. In this enzyme complex, a variety of F-box proteins act as receptors that recruit substrates. We have identified a fission yeast gene encoding a novel F-box protein Pof3, which contains, in addition to the F-box, a tetratricopeptide repeat motif in its N terminus and a leucine-rich-repeat motif in the C terminus, two ubiquitous protein–protein interaction domains. Pof3 forms a complex with Skp1 and Pcu1 (fission yeast cullin-1), suggesting that Pof3 functions as an adaptor for specific substrates. In the absence of Pof3, cells exhibit a ...
Subjects
free text keywords: Cell Biology, Molecular Biology, Biology, Chromatin, Mutant, G2-M DNA damage checkpoint, Tetratricopeptide, Ubiquitin ligase, biology.protein, Cell cycle, Mitosis, F-box protein, Article
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publication . Article . Other literature type . 2002

Fission Yeast F-box Protein Pof3 Is Required for Genome Integrity and Telomere Function

Katayama, Satoshi; Kitamura, Kenji; Lehmann, Anna; Nikaido, Osamu; Toda, Takashi;