publication . Other literature type . Article . 2011

Effect of Grewia Gum as a Suspending Agent on Ibuprofen Pediatric Formulation

Ikoni Joshua Ogaji; Stephen W. Hoag;
Open Access English
  • Published: 14 Apr 2011
  • Publisher: Springer US
Abstract
The purpose of this work was to evaluate the potential of grewia gum (GG) as a suspending agent in pharmaceutical oral formulation using ibuprofen as model drug. Ibuprofen pediatric suspension (25 mg/5 mL) was formulated with grewia gum (0.5% w/v) as the suspending agent. Similar suspensions of Ibuprofen containing either sodium carboxymethylcellulose (Na-CMC) or hydroxymethylpropylcellulose (HPMC) were also produced. The suspensions were evaluated for ease of redispersion, sedimentation, rheological properties, and the effect of aging on the rheological properties at 25°C. The particle size and particle size distributions of the dispersed solute were determined...
Subjects
free text keywords: Research Article, Agronomy and Crop Science, Ecology, Aquatic Science, Ecology, Evolution, Behavior and Systematics, Drug Discovery, Pharmaceutical Science, General Medicine, Grewia, biology.organism_classification, biology, Rheology, Suspension (vehicle), Particle size, Sodium carboxymethylcellulose, Viscosity, Chemistry, Ibuprofen, medicine.drug, medicine, Chromatography
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publication . Other literature type . Article . 2011

Effect of Grewia Gum as a Suspending Agent on Ibuprofen Pediatric Formulation

Ikoni Joshua Ogaji; Stephen W. Hoag;