publication . Article . 2015

MicroRNA-34a-5p enhances sensitivity to chemotherapy by targeting AXL in hepatocellular carcinoma MHCC-97L cells

LI, XIAO-YUN; WEN, JING-YUN; JIA, CHANG-CHANG; WANG, TIAN-TIAN; LI, XING; DONG, MIN; LIN, QU; CHEN, ZHAN-HONG; MA, XIAO-KUN; WEI, LI; ...
Open Access
  • Published: 01 Aug 2015 Journal: Oncology Letters, volume 10, pages 2,691-2,698 (issn: 1792-1074, eissn: 1792-1082, Copyright policy)
  • Publisher: Spandidos Publications
Abstract
Mature microRNA (miRNA) 34a-5p, which is a well-known tumor suppressor in hepatitis virus-associated hepatocellular carcinoma (HCC), plays an important role in cell processes, such as cell proliferation and apoptosis, and is therefore an optimal biomarker for future clinical use. However, the role of miRNA-34a-5p in chemoresistance has yet to be identified. In the present study, the expression of miRNA-34a-5p was assessed by an in situ hybridization assay in HCC tissues and was found to be significantly decreased compared with the pericarcinomatous areas of the tissue specimens, which consisted of samples obtained from 114 patients with HCC. High expression of m...
Subjects
Medical Subject Headings: digestive system diseases
free text keywords: microRNA, Oncogene, Transfection, Hepatocellular carcinoma, medicine.disease, medicine, MicroRNA 34a, Cell cycle, Immunology, Cell, medicine.anatomical_structure, Cisplatin, medicine.drug, Cancer research, business.industry, business, Articles, microRNA34a-5p, chemoresistance, AXL
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publication . Article . 2015

MicroRNA-34a-5p enhances sensitivity to chemotherapy by targeting AXL in hepatocellular carcinoma MHCC-97L cells

LI, XIAO-YUN; WEN, JING-YUN; JIA, CHANG-CHANG; WANG, TIAN-TIAN; LI, XING; DONG, MIN; LIN, QU; CHEN, ZHAN-HONG; MA, XIAO-KUN; WEI, LI; ...