EGFR tyrosine kinase targeted compounds: in vitro antitumor activity and molecular modeling studies of new benzothiazole and pyrimido[2,1-b]benzothiazole derivatives

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Gabr, Moustafa T.; El-Gohary, Nadia S; El-Bendary, Eman R.; El-Kerdawy, Mohamed M.;
(2014)
  • Publisher: Leibniz Research Centre for Working Environment and Human Factors
  • Journal: EXCLI Journal, volume 13, pages 573-585 ( eissn: 1611-2156)
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC4464492
  • Subject: Original Article | antitumor activity | molecular modeling | benzothiazoles | pyrimidobenzothiazoles | EGFR tyrosine kinase inhibitory activity

In this study, we illustrate computer aided drug design of new benzothiazole and pyrimido[2,1-b]benzothiazole derivatives as epidermal growth factor receptor tyrosine kinase (EGFR-TK) inhibitors. Compounds 1-5 were screened at NCI, USA, for antitumor activity against no... View more
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