Interest of integrins targeting in glioblastoma according to tumor heterogeneity and cancer stem cell paradigm: an update

Article English OPEN
Malric, Laure; Monferran, Sylvie; Gilhodes, Julia; Boyrie, Sabrina; Dahan, Perrine; Skuli, Nicolas; Sesen, Julie; Filleron, Thomas; Kowalski-Chauvel, Aline; Cohen-Jonathan Moyal, Elizabeth; Toulas, Christine; Lemarié, Anthony;
  • Publisher: Impact Journals LLC
  • Journal: Oncotarget,volume 8,issue 49,pages86,947-86,968 (eissn: 1949-2553)
  • Related identifiers: doi: 10.18632/oncotarget.20372, pmc: PMC5689739
  • Subject: targeted therapy | integrins | glioblastoma | Review | clinical trials | cancer stem cells
    mesheuropmc: nervous system diseases | neoplasms

Glioblastomas are malignant brain tumors with dismal prognosis despite standard treatment with surgery and radio/chemotherapy. These tumors are defined by an important cellular heterogeneity and notably contain a particular subpopulation of Glioblastoma-initiating cells... View more
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