publication . Other literature type . Article . 2019

Patients with Idiopathic Pulmonary Nontuberculous Mycobacterial Disease Have Normal Th1/Th2 Cytokine Responses but Diminished Th17 Cytokine and Enhanced Granulocyte-Macrophage Colony-Stimulating Factor Production

Un-In Wu; Kenneth N Olivier; Douglas B Kuhns; Danielle L Fink; Elizabeth P Sampaio; Adrian M Zelazny; Shamira J Shallom; Beatriz E Marciano; Michail S Lionakis; Steven M Holland;
Open Access English
  • Published: 28 Nov 2019
  • Publisher: Oxford University Press
Abstract
<jats:title>Abstract</jats:title> <jats:sec> <jats:title>Objective</jats:title> <jats:p>Although disseminated nontuberculous mycobacterial infection is attributed to defects in the interleukin (IL)-12/interferon-γ circuit, the immunophenotype of idiopathic pulmonary nontuberculous mycobacterial (PNTM) disease is not well defined.</jats:p> </jats:sec> <jats:sec> <jats:title>Method</jats:title> <jats:p>We phenotyped Th1, Th2, Th17, and Treg cytokines and colony-stimulating factor production from patients with idiopathic PNTM disease. Data were compared with healthy donors, cystic fibrosis (CF), and primary ciliary dyskinesia (PCD) patients with PNTM disease. Both ...
Subjects
free text keywords: Major Articles, Oncology, Clinical Neurology, Granulocyte macrophage colony-stimulating factor, medicine.drug, medicine, Virology, Cystic fibrosis, medicine.disease, Lung, medicine.anatomical_structure, Interleukin 12, Immunophenotyping, Interleukin, Interferon, business.industry, business, Cytokine, medicine.medical_treatment, Immunology
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publication . Other literature type . Article . 2019

Patients with Idiopathic Pulmonary Nontuberculous Mycobacterial Disease Have Normal Th1/Th2 Cytokine Responses but Diminished Th17 Cytokine and Enhanced Granulocyte-Macrophage Colony-Stimulating Factor Production

Un-In Wu; Kenneth N Olivier; Douglas B Kuhns; Danielle L Fink; Elizabeth P Sampaio; Adrian M Zelazny; Shamira J Shallom; Beatriz E Marciano; Michail S Lionakis; Steven M Holland;