publication . Other literature type . 1996

Induction of antigen-specific tumor immunity by genetic and cellular vaccines against MAGE: enhanced tumor protection by coexpression of granulocyte-macrophage colony-stimulating factor and B7-1.

Büeler, H.; Mulligan, R. C.;
Open Access English
  • Published: 01 Sep 1996
  • Publisher: The Feinstein Institute for Medical Research
Abstract
BACKGROUND: A number of tumors express antigens that are recognized by specific cytotoxic T cells. The normal host immune responses, however, are not usually sufficient to cause tumor rejection. Using appropriate immunization strategies, tumor-specific antigens may serve as targets against which tumor-destructive immune responses can be generated. MAGE-1 and MAGE-3 are two clinically relevant antigens expressed in many human melanomas and other tumors, but not in normal tissues, except testis. Here, we have investigated whether DNA and cellular vaccines against MAGE-1 and MAGE-3 can induce antigen-specific anti-tumor immunity and cause rejection of MAGE-expressi...
Subjects
Medical Subject Headings: neoplasmsendocrine system
free text keywords: Research Article
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Other literature type . 1996
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