publication . Article . Other literature type . 2010

An Inherited Variable Poly-T Repeat Genotype in TOMM40 in Alzheimer Disease

Roses, Allen D.;
Open Access
  • Published: 01 May 2010 Journal: Archives of Neurology, volume 67 (issn: 0003-9942, Copyright policy)
  • Publisher: American Medical Association (AMA)
Abstract
I coauthored a recently published research paper demonstrating that a variable length, poly-T polymorphism in the TOMM40 (Translocase of the Outer Mitochondrial Membrane 40 homolog (yeast)) gene, which lies adjacent to APOE on chromosome 19, accounts for the age of onset distribution for a complex disease, late-onset Alzheimer's disease (LOAD).1 These new data explain the average age of disease onset for patients with the APOE4/4 genotype, and differentiate two forms of TOMM40 poly-T polymorphisms linked to APOE with each form associated with a different age of disease onset distribution.2 When linked to APOE3, the longer TOMM40 poly-T repeats (19–39 nucleotides...
Subjects
free text keywords: Arts and Humanities (miscellaneous), Clinical Neurology, Common disease-common variant, Genetics, Genotype, Age of onset, Biology, Allele, Locus (genetics), Allele frequency, Polymorphism (computer science), Apolipoprotein E, Article
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publication . Article . Other literature type . 2010

An Inherited Variable Poly-T Repeat Genotype in TOMM40 in Alzheimer Disease

Roses, Allen D.;