Quantitative Three Dimensional Structure Linear Interaction Energy Model of 5'-O-[N-(Salicyl)sulfamoyl]adenosine and the Aryl Acid Adenylating Enzyme MbtA

Other literature type English OPEN
Labello, Nicholas P.; Bennett, Eric M.; Ferguson, David M.; Aldrich, Courtney C.;

MbtA (a salicyl AMP ligase) is a key target for the design of new antitubercular agents. Based on structure activity relationship (SAR) data generated in our laboratory, a structure-based model is developed to predict the binding affinities of arylacid-AMP bisubstrate i... View more
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