publication . Article . 2017

Elevated Serum Cyclophilin B Levels Are Associated with the Prevalence and Severity of Metabolic Syndrome

Hang Zhang; Hang Zhang; Qin Fan; Qin Fan; Hongyang Xie; Hongyang Xie; Lin Lu; Lin Lu; Rong Tao; Fang Wang; ...
Open Access English
  • Published: 01 Dec 2017 Journal: Frontiers in Endocrinology, volume 8 (eissn: 1664-2392, Copyright policy)
  • Publisher: Frontiers Media S.A.
ObjectiveInflammation plays a central role in the pathogenesis of metabolic syndrome (MetS). Cyclophilin B (CypB) can be constitutively secreted in response to inflammatory stimuli and oxidative stress, participating in tissue or systemic inflammation. We investigated the relationship between CypB and MetS in both humans and mice.MethodsSerum CypB levels were determined in 211 subjects with MetS and 292 subjects without MetS (non-MetS) (133 healthy controls and 159 high-risk subjects with one to two MetS components). Additionally, CypB expression in metabolic organs was examined in mice fed with high-fat diet (HFD) and genetically obese (ob/ob) mice.ResultsSerum...
free text keywords: Endocrinology, Original Research, cyclophilin B, CD147, metabolic syndrome, inflammation, cardiovascular risk, Diseases of the endocrine glands. Clinical endocrinology, RC648-665, Pathogenesis, medicine.disease, medicine, Biomarker (medicine), Systemic inflammation, medicine.symptom, Diabetes mellitus, medicine.medical_specialty, Biology, Internal medicine, Oxidative stress, medicine.disease_cause
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