DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?

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Passos, João F.; Saretzki, Gabriele; von Zglinicki, Thomas;

Cellular senescence is the ultimate and irreversible loss of replicative capacity occurring in primary somatic cell culture. It is triggered as a stereotypic response to unrepaired nuclear DNA damage or to uncapped telomeres. In addition to a direct role of nuclear DNA ... View more
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