DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?

Article English OPEN
Passos, João F. ; Saretzki, Gabriele ; von Zglinicki, Thomas (2007)
  • Publisher: Oxford University Press
  • Journal: Nucleic Acids Research, volume 35, issue 22, pages 7,505-7,513 (issn: 0305-1048, eissn: 1362-4962)
  • Related identifiers: pmc: PMC2190715, doi: 10.1093/nar/gkm893
  • Subject: Survey and Summary

Cellular senescence is the ultimate and irreversible loss of replicative capacity occurring in primary somatic cell culture. It is triggered as a stereotypic response to unrepaired nuclear DNA damage or to uncapped telomeres. In addition to a direct role of nuclear DNA ... View more
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