DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?
Passos, João F.
von Zglinicki, Thomas
- Publisher: Oxford University Press
Nucleic Acids Research,
(issn: 0305-1048, eissn: 1362-4962)
Survey and Summary
Cellular senescence is the ultimate and irreversible loss of replicative capacity occurring in primary somatic cell culture. It is triggered as a stereotypic response to unrepaired nuclear DNA damage or to uncapped telomeres. In addition to a direct role of nuclear DNA ...