publication . Article . 2018

Matrix Effect Study and Immunoassay Detection Using Electrolyte-Gated Graphene Biosensor

Sun, Jianbo; Liu, Yuxin;
Open Access English
  • Published: 01 Mar 2018 Journal: Micromachines, volume 9, issue 4 (eissn: 2072-666X, Copyright policy)
  • Publisher: MDPI
Significant progress has been made on the development of electrolyte-gated graphene field effect transistor (EGGFET) biosensors over the last decade, yet they are still in the stage of proof-of-concept. In this work, we studied the electrolyte matrix effects, including its composition, pH and ionic strength, and demonstrate that variations in electrolyte matrices have a significant impact on the Fermi level of the graphene channel and the sensitivity of the EGGFET biosensors. This is attributed to the polarization-induced interaction between the electrolyte and the graphene at the interface which can lead to considerable modulation of the Fermi level of the grap...
free text keywords: Article, graphene, electrolyte-gated field effect transistor, matrix effect, immunoassay
Funded by
NIH| Multiplexed Detection of Traumatic Brain Injury Biomarkers with An Optical Latera
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1R15NS087515-01
29 references, page 1 of 2

Liu, S., Guo, X.. Carbon nanomaterials field-effect-transistor-based biosensors. NPG Asia Mater.. 2012; 4: e23 [OpenAIRE] [DOI]

Forsyth, R., Devadoss, A., Guy, O.J.. Graphene field effect transistors for biomedical applications: Current status and future prospects. Diagnostics. 2017; 7 [OpenAIRE] [PubMed] [DOI]

Zhang, A., Lieber, C.M.. Nano-Bioelectronics. Chem. Rev.. 2016; 116: 215-257 [OpenAIRE] [PubMed] [DOI]

Dankerl, M., Hauf, M.V., Lippert, A., Hess, L.H., Birner, S., Sharp, I.D., Mahmood, A., Mallet, P., Veuillen, J.-Y., Stutzmann, M.. Graphene solution-gated field-effect transistor array for sensing applications. Adv. Funct. Mater.. 2010; 20: 3117-3124 [OpenAIRE] [DOI]

He, Q., Wu, S., Yin, Z., Zhang, H.. Graphene-based electronic sensors. Chem. Sci.. 2012; 3: 1764 [OpenAIRE] [DOI]

Mohanty, N., Berry, V.. Graphene-based single-bacterium resolution biodevice and DNA transistor: interfacing graphene derivatives with nanoscale and microscale biocomponents. Nano Lett.. 2008; 8: 4469-4476 [OpenAIRE] [PubMed] [DOI]

Ohno, Y., Maehashi, K., Yamashiro, Y., Matsumoto, K.. Electrolyte-gated graphene field-effect transistors for detecting pH and protein adsorption. Nano Lett.. 2009; 9: 3318-3322 [OpenAIRE] [PubMed] [DOI]

Huang, Y., Dong, X., Shi, Y., Li, C.M., Li, L.-J., Chen, P.. Nanoelectronic biosensors based on CVD grown graphene. Nanoscale. 2010; 2: 1485 [OpenAIRE] [PubMed] [DOI]

Jiang, S., Cheng, R., Wang, X., Xue, T., Liu, Y., Nel, A., Huang, Y., Duan, X.. Real-time electrical detection of nitric oxide in biological systems with sub-nanomolar sensitivity. Nat. Commun.. 2013; 4 [OpenAIRE] [PubMed] [DOI]

Zhang, B., Li, Q., Cui, T.. Ultra-sensitive suspended graphene nanocomposite cancer sensors with strong suppression of electrical noise. Biosens. Bioelectron.. 2012; 31: 105-109 [OpenAIRE] [PubMed] [DOI]

Hess, L.H., Jansen, M., Maybeck, V., Hauf, M.V., Seifert, M., Stutzmann, M., Sharp, I.D., Offenhäusser, A., Garrido, J.A.. Graphene transistor arrays for recording action potentials from electrogenic cells. Adv. Mater.. 2011; 23: 5045-5049 [OpenAIRE] [PubMed] [DOI]

Cheng, Z., Hou, J., Zhou, Q., Li, T., Li, H., Yang, L., Jiang, K., Wang, C., Li, Y., Fang, Y.. Sensitivity Limits and Scaling of Bioelectronic Graphene Transducers. Nano Lett.. 2013; 13: 2902-2907 [OpenAIRE] [PubMed] [DOI]

Gao, N., Gao, T., Yang, X., Dai, X., Zhou, W., Zhang, A., Lieber, C.M.. Specific detection of biomolecules in physiological solutions using graphene transistor biosensors. Proc. Natl. Acad. Sci. USA. 2016; 113: 14633-14638 [OpenAIRE] [PubMed] [DOI]

Kulkarni, G.S., Zhong, Z.. Detection beyond the Debye Screening Length in a High-frequency nanoelectronic biosensor. Nano Lett.. 2012; 12: 719-723 [OpenAIRE] [PubMed] [DOI]

Ohno, Y., Maehashi, K., Inoue, K., Matsumoto, K.. Label-Free Aptamer-based immunoglobulin sensors using graphene field-effect transistors. Jpn. J. Appl. Phys.. 2011; 50: 070120 [OpenAIRE] [DOI]

29 references, page 1 of 2
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