publication . Article . 2018

Matrix Effect Study and Immunoassay Detection Using Electrolyte-Gated Graphene Biosensor

Sun, Jianbo; Liu, Yuxin;
Open Access English
  • Published: 01 Mar 2018 Journal: Micromachines, volume 9, issue 4 (eissn: 2072-666X, Copyright policy)
  • Publisher: MDPI
Abstract
Significant progress has been made on the development of electrolyte-gated graphene field effect transistor (EGGFET) biosensors over the last decade, yet they are still in the stage of proof-of-concept. In this work, we studied the electrolyte matrix effects, including its composition, pH and ionic strength, and demonstrate that variations in electrolyte matrices have a significant impact on the Fermi level of the graphene channel and the sensitivity of the EGGFET biosensors. This is attributed to the polarization-induced interaction between the electrolyte and the graphene at the interface which can lead to considerable modulation of the Fermi level of the grap...
Subjects
free text keywords: Article, graphene, electrolyte-gated field effect transistor, matrix effect, immunoassay
Funded by
NIH| Multiplexed Detection of Traumatic Brain Injury Biomarkers with An Optical Latera
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1R15NS087515-01
  • Funding stream: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
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