A controlled human malaria infection model enabling evaluation of transmission-blocking interventions

Article English OPEN
Collins, Katharine A.; Wang, Claire Y.T.; Adams, Matthew; Mitchell, Hayley; Rampton, Melanie; Elliott, Suzanne; Reuling, Isaie J.; Bousema, Teun; Sauerwein, Robert; Chalon, Stephan; Möhrle, Jörg J.; McCarthy, James S.;
  • Publisher: American Society for Clinical Investigation
  • Journal: The Journal of Clinical Investigation,volume 128,issue 4,pages1,551-1,562 (issn: 0021-9738, eissn: 1558-8238)
  • Related identifiers: pmc: PMC5873858, doi: 10.1172/JCI98012
  • Subject: Clinical Medicine | Infectious disease | Clinical Trials | Malaria
    mesheuropmc: parasitic diseases

BACKGROUND. Drugs and vaccines that can interrupt the transmission of Plasmodium falciparum will be important for malaria control and elimination. However, models for early clinical evaluation of candidate transmission-blocking interventions are currently unavailable. H... View more
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