Multinucleotide mutations cause false inferences of lineage-specific positive selection

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Venkat, Aarti; Hahn, Matthew W.; Thornton, Joseph W.;

Phylogenetic tests of adaptive evolution, such as the widely used branch-site test, assume that nucleotide substitutions occur singly and independently. But recent research has shown that errors at adjacent sites often occur during DNA replication, and the resulting mul... View more
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