publication . Article . 2017

New fluphenazine analogue with antimutagenic and anti-multidrug resistance activity—degradation profile and stability-indicating method

Agnieszka Sobczak; Artur Teżyk; Joanna Szyndlarewicz; Jan Ziarniak; Piotr Świątek; Wiesław Malinka;
Open Access English
  • Published: 15 Jun 2017 Journal: Medicinal Chemistry Research, volume 26, issue 10, pages 2,443-2,451 (issn: 1054-2523, eissn: 1554-8120, Copyright policy)
  • Publisher: Springer US
Abstract
Hydrochloride of 10-{2-hydroxy-3-[N,N-bis-(2-hydroxyethyl)amino]propyl}-2-trifluoromethylphenothiazine (Flu-A) is a analogue of neuroleptic fluphenazine. Flu-A exhibits anti-multidrug resistance, antimutagenic, proapoptopic, and cancer-chemopreventive activities in screening studies. To define identity, quality, and purity of new active substance it is necessary to develop a appropriate analytical method and to establish a degradation profile. Thus, a stability-indicating reversed-phase high-performance liquid chromatography method was developed and validated for quantitative determination of Flu-A in the presence of its degradation products generated under stre...
Subjects
free text keywords: Original Research, Kinetics, Stability test, Degradation products, Phenothiazine analogue, HPLC, Mass spectrometry, General Pharmacology, Toxicology and Pharmaceutics, Organic Chemistry, Chromatography, High-performance liquid chromatography, Aqueous solution, Hydrochloride, chemistry.chemical_compound, chemistry, Photodissociation, Fluphenazine, medicine.drug, medicine, Degradation (geology)
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