publication . Other literature type . Article . 2015

Daptomycin resistance

Truc T. Tran; Jose M. Munita; Cesar A. Arias;
  • Published: 01 Sep 2015
  • Publisher: Wiley
Abstract
Daptomycin (DAP) is a cyclic lipopeptide with in vitro activity against a variety of Gram-positive pathogens, including multidrug-resistant organisms. Since its introduction in clinical practice in 2003, DAP has become an important key front-line antibiotic for severe or deep-seated infections caused by Gram-positive organisms. Unfortunately, DAP-resistance (R) has been extensively documented in clinically important organisms such as Staphylococcus aureus, Enterococcus spp, and Streptococcus spp. Studies on the mechanisms of DAP-R in Bacillus subtilis and other Gram-positive bacteria indicate that the genetic pathways of DAP resistance are diverse and complex. H...
Subjects
free text keywords: Article, General Biochemistry, Genetics and Molecular Biology, History and Philosophy of Science, Cell envelope, Cell membrane, medicine.anatomical_structure, medicine, Microbiology, Antibiotics, medicine.drug_class, Drug resistance, Daptomycin, medicine.drug, Biology, Lipopeptide, chemistry.chemical_compound, chemistry, Bacterial cell structure, Immunology, Bacteria, biology.organism_classification
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publication . Other literature type . Article . 2015

Daptomycin resistance

Truc T. Tran; Jose M. Munita; Cesar A. Arias;