publication . Article . 2009

Nutritional and Physicochemical Characteristics of the Antidementia Acetylcholinesterase-Inhibiting Methanol Extracts from Umbilicaria esculenta

Ji-Su Lee; Gyung-Hun Min; Jong-Soo Lee;
Open Access English
  • Published: 01 Sep 2009 Journal: Mycobiology, volume 37, issue 3, pages 203-206 (issn: 1229-8093, eissn: 2092-9323, Copyright policy)
  • Publisher: The Korean Society of Mycology
Abstract
Alzheimer's disease is characterized by acetylcholine depletion, amyloid β protein aggregation, and neurofibrillary tangle (Duyckaerts et al., 1999). The neurotransmitter acetylcholine has important recognition functions such as memory (Richter et al., 1980), and it is synthesized in certain neurons by the enzyme choline acetyltransferase from choline and acetyl-CoA. Acetylcholinesterase (AChE) [EC 3.1.1.7] is an enzyme that hydrolyses acetylcholine into choline and acetate. Therefore, it promotes dementia by loss of neurotransmitter in the brain. Many AChE inhibitors have been developed from natural products and ultimately commercialized. However, commercial AC...
Subjects
free text keywords: Research Article, Antidementia, Acetylcholinesterase inhibitor, Umbilicaria esculenta, Plant Science, Microbiology, Infectious Diseases, Biology, biology.organism_classification, Usnic acid, chemistry.chemical_compound, chemistry, Acetylcholine, medicine.drug, medicine, Choline acetyltransferase, Acetylcholinesterase, Vulpinic acid, Biochemistry, medicine.drug_class, Parietin, Botany
Related Organizations

Choi, HJ, Kim, NJ, Kim, DH. Inhibitory effect of GE974 isolated from Gyrophora esculenta on α-glucosidase. Korean J Pharmacogn. 2000; 31: 196-202

Dubios, B, Albert, ML. MCI or prodromal Alzheimer's disease. Lancet Neurol. 2004; 3: 246-248 [PubMed]

Duyckaerts, C, Colle, MA, Delatour, B, Hauw, JJ. Alzheimer's disease: lesions and their progression. Rev Neurol. 1999; 155: 17-27 [OpenAIRE]

Ellman, GL, Courtney, KD, Andres, V, Featherstone, RM. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol. 1961; 7: 68-75 [OpenAIRE]

Hawksworth, DL, Galun, M. CRC Handbook of Lichennology. 1988; Vol. I: 35-38

Hawksworth, DL, Hill, DJ. The lichen-forming fungi. 1984: 116-129

Jang, CH, Eun, JS, Park, HW, Seo, SM, Yang, JH, Leem, KH, Oh, SH, Oh, CH, Baek, NI, Kim, DK. An acetylcholinesterase inhibitor from the leaves of Securinega suffruticosa. Korean J Pharmacogn. 2003; 34: 14-17

Kim, HK, Lee, EN, Geum, JW, Lee, JS. Nutritional characteristics and physiological functionalities of polyplant extracts from some vegetables and medicinal plants. Korean J Food Nutr. 2008; 21: 410-415

Kim, JW, Song, KS, Chang, HW, Yu, SH, Yoo, ID. A phospholipase A2 inhibitor isolated from Umbilicaria esculenta. J Microbiol Biotechnol. 1995; 23: 526-530

Kim, MS, Lee, KA. Antithrombotic activity of methanolic extract of Umbilicaria esculenta. J Ethnopharmacol. 2006; 105: 342-345 [PubMed]

Lee, KA, Kim, MS. Effect of extract from Umbilicaria esculenta on postprandail hyperglycemia. Korean J Pharmacogn. 1999; 31: 101-104

Muramoto, O, Sugishita, M, Sugita, H, Toyokura, T. Effect of physostigmine on constructional and memory tasks in Alzheimer's disease. Arch Neurol. 1979; 38: 501-503 [OpenAIRE] [PubMed]

Richter, JA, Perry, EK, Tomlinson, BE. Acetylcholine and choline levels in postmortem human brain tissue: preliminary observation in Alzheimer's disease. Life Sci. 1980; 26: 1683-1689 [PubMed]

Song, JE, Lee, JS. Physicochemical characteristics of antidementia acetylcholinesterase inhibitor-containing methanol extracts from Sorghum bicolor and industrial application. J Natural Sci of Paichai Univ. 2008; 19: 45-55

Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Article . 2009

Nutritional and Physicochemical Characteristics of the Antidementia Acetylcholinesterase-Inhibiting Methanol Extracts from Umbilicaria esculenta

Ji-Su Lee; Gyung-Hun Min; Jong-Soo Lee;