publication . Other literature type . Article . 2006

Aurintricarboxylic Acid Inhibits the Early Stage of Vaccinia Virus Replication by Targeting both Cellular and Viral Factors▿

Chad Myskiw; Yvon Deschambault; Kristel Jefferies; Runtao He; Jingxin Cao;
Open Access English
  • Published: 27 Dec 2006
  • Publisher: American Society for Microbiology
Abstract
<jats:title>ABSTRACT</jats:title> <jats:p>Aurintricarboxylic acid (ATA) has been shown to inhibit the replication of viruses from several different families, including human immunodeficiency virus, vesicular stomatitis virus, and the coronavirus causing severe acute respiratory syndrome. This study characterizes the inhibitory effect of ATA on vaccinia virus replication in HeLa, Huh7, and AD293 cells. Vaccinia virus replication is significantly abrogated upon ATA treatment, which is associated with the inhibition of early viral gene transcription. This inhibitory effect may be attributed to two findings. First, ATA blocks the phosphorylation of extracellular sig...
Subjects
Medical Subject Headings: viruses
free text keywords: Genome Replication and Regulation of Viral Gene Expression, Immunology, Insect Science, Microbiology, Virology, Vaccinia, chemistry.chemical_compound, chemistry, Coronavirus, medicine.disease_cause, medicine, Aurintricarboxylic acid, Orthopoxvirus, biology.organism_classification, biology, Virus, Viral replication, Vesicular stomatitis virus, Molecular biology, Poxviridae
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publication . Other literature type . Article . 2006

Aurintricarboxylic Acid Inhibits the Early Stage of Vaccinia Virus Replication by Targeting both Cellular and Viral Factors▿

Chad Myskiw; Yvon Deschambault; Kristel Jefferies; Runtao He; Jingxin Cao;