publication . Article . 2010

Armadillo Repeat Containing 8α Binds to HRS and Promotes HRS Interaction with Ubiquitinated Proteins

Koji Tomaru; Atsuhisa Ueda; Takeyuki Suzuki; Nobuaki Kobayashi; Jun Yang; Masaki Yamamoto; Mitsuhiro Takeno; Takeshi Kaneko; Yoshiaki Ishigatsubo;
Open Access English
  • Published: 13 Jan 2010 Journal: The Open Biochemistry Journal, volume 4, pages 1-8 (eissn: 1874-091X, Copyright policy)
  • Publisher: Bentham Open
Abstract
Recently, we reported that a complex with an essential role in the degradation of Fructose-1,6-bisphosphatase in yeast is well conserved in mammalian cells; we named this mammalian complex C-terminal to the Lissencephaly type-1-like homology (CTLH) complex. Although the function of the CTLH complex remains unclear, here we used yeast two-hybrid screening to isolate Hepatocyte growth factor-regulated tyrosine kinase substrate (HRS) as a protein binding to a key component of CTLH complex, Armadillo repeat containing 8 (ARMc8) α. The association was confirmed by a yeast two-hybrid assay and a co-immunoprecipitation assay. The proline-rich domain of HRS was essentia...
Subjects
free text keywords: Article, ARMc8α, FBPase, monoubiquitination, HRS, UIM., General Biochemistry, Genetics and Molecular Biology, Biology, Biochemistry, Plasma protein binding, Armadillo repeats, Homology (biology), Tyrosine kinase, Endosome, Hepatocyte, medicine.anatomical_structure, medicine, Yeast
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publication . Article . 2010

Armadillo Repeat Containing 8α Binds to HRS and Promotes HRS Interaction with Ubiquitinated Proteins

Koji Tomaru; Atsuhisa Ueda; Takeyuki Suzuki; Nobuaki Kobayashi; Jun Yang; Masaki Yamamoto; Mitsuhiro Takeno; Takeshi Kaneko; Yoshiaki Ishigatsubo;