publication . Article . Other literature type . 2019

Cyclodextrin–Amphiphilic Copolymer Supramolecular Assemblies for the Ocular Delivery of Natamycin

Thorsteinn Loftsson; Blanca Lorenzo-Veiga; Hakon H. Sigurdsson; Carmen Alvarez-Lorenzo;
Open Access English
  • Published: 15 May 2019
  • Publisher: MDPI AG
Abstract
s Egg Test on the Chorioallantoic Membrane (HET-CAM) assay. Poly(pseudo)rotaxanes facilitated drug accumulation into the cornea and sclera, but led to lower natamycin permeability through the sclera than the corresponding micelles. Poly(pseudo)rotaxanes made from mixed micelles showed intermediate natamycin diffusion coefficients and permeability values between those of Pluronic P103-based and Soluplus-based poly(pseudo)rotaxanes. Therefore, the preparation of mixed micelles may be a useful tool to regulate drug release and enhance ocular permeability.
doi: 10.3390/nano9050745
handle: 10347/21337
pmc: PMC6566826 ...
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Subjects
free text keywords: Block copolymers, Cyclodextrins, Fungal keratitis, HET-CAM assay, Mixed micelles, Natamycin, Ocular drug delivery, Ocular permeability, Poly(pseudo)rotaxane, Solubility, Lyfjafræði, Lyfjagerð, Sýklódextrín, Chemistry, QD1-999, Polyrotaxane, Polypseudorotaxane, Article, medicine.drug, medicine, Chemical engineering, Cyclodextrin, chemistry.chemical_classification, Zeta potential, Permeation, Supramolecular chemistry, Poloxamer, Micelle
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