publication . Other literature type . 2010

Lipid Phosphate Phosphatase 3 Stabilization of β-Catenin Induces Endothelial Cell Migration and Formation of Branching Point Structures▿ †

Humtsoe, Joseph O.; Liu, Mingyao; Malik, Asrar B.; Wary, Kishore K.;
Open Access English
  • Published: 01 Feb 2010
  • Publisher: American Society for Microbiology (ASM)
Abstract
Endothelial cell (EC) migration, cell-cell adhesion, and the formation of branching point structures are considered hallmarks of angiogenesis; however, the underlying mechanisms of these processes are not well understood. Lipid phosphate phosphatase 3 (LPP3) is a recently described p120-catenin-associated integrin ligand localized in adherens junctions (AJs) of ECs. Here, we tested the hypothesis that LPP3 stimulates β-catenin/lymphoid enhancer binding factor 1 (β-catenin/LEF-1) to induce EC migration and formation of branching point structures. In subconfluent ECs, LPP3 induced expression of fibronectin via β-catenin/LEF-1 signaling in a phosphatase and tensin ...
Subjects
mesheuropmc: animal structures
free text keywords: Articles
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