Concentration-dependent exchange accelerates turnover of proteins bound to double-stranded DNA

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Graham, John S.; Johnson, Reid C.; Marko, John F.;
(2010)

The multistep kinetics through which DNA-binding proteins bind their targets are heavily studied, but relatively little attention has been paid to proteins leaving the double helix. Using single-DNA stretching and fluorescence detection, we find that sequence-neutral DN... View more