Concentration-dependent exchange accelerates turnover of proteins bound to double-stranded DNA
Graham, John S.
Johnson, Reid C.
Marko, John F.
- Publisher: Oxford University Press
Nucleic Acids Research,
(issn: 0305-1048, eissn: 1362-4962)
The multistep kinetics through which DNA-binding proteins bind their targets are heavily studied, but relatively little attention has been paid to proteins leaving the double helix. Using single-DNA stretching and fluorescence detection, we find that sequence-neutral DN...