Mce2 operon mutant strain of Mycobacterium tuberculosis is attenuated in C57BL/6 mice

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Marjanovic, Olivera; Miyata, Toshiko; Goodridge, Amador; Kendall, Lon V.; Riley, Lee W.;

Mycobacterium tuberculosis genome contains four related sets of an operon called mce (mce1-4). The disruption of one of these operons, mce1, causes M. tuberculosis to become hypervirulent, whereas the mce3 and mce4 operon mutants are attenuated in mice. This study exami... View more
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