publication . Other literature type . Article . 1994

Lateral inhibition mediated by the Drosophila neurogenic gene delta is enhanced by proneural proteins.

M. Kunisch; M. Haenlin; J. A. Campos-Ortega;
Open Access English
  • Published: 11 Oct 1994
Abstract Cells in the neuroectoderm of Drosophila become either neural or epidermal progenitors. A critical threshold concentration of proneural gene products in a given cell causes it to develop as a neuroblast. The proteins encoded by the genes Delta (Dl) and Notch (N) act as the source and the receptor, respectively, of inhibitory signals sent by the neuroblast to neighboring cells that prevent these cells from also adopting the neural fate. We show here that proneural gene products activate transcription of Delta in the neuroectoderm by binding to specific sites in its promoter. This transcriptional activation enhances lateral inhibition and thus helps ensur...
Medical Subject Headings: animal structuresembryonic structures
free text keywords: Research Article, Multidisciplinary, Neuroectoderm, Transcription (biology), Neuroblast, DNA-binding protein, Lateral inhibition, Molecular biology, Gene, Biology, Membrane protein, Regulation of gene expression
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