Effects of a serotonin 5-HT4 receptor antagonist SB-207266 on gastrointestinal motor and sensory function in humans

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Bharucha, A; Camilleri, M; Haydock, S; Ferber, I; Burton, D; Cooper, S; Tompson, D; Fitzpatrick, K; Higgins, R; Zinsmeister, A;

BACKGROUND—Serotonin 5-HT4 receptors are located on enteric cholinergic neurones and may regulate peristalsis. 5-HT4 receptors on primary afferent neurones have been postulated to modulate visceral sensation. While 5-HT4 agonists are used as prokinetic agents, the physi... View more
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