publication . Other literature type . Article . 2016

Polymorphisms in α-Defensin–Encoding DEFA1A3 Associate with Urinary Tract Infection Risk in Children with Vesicoureteral Reflux

Schwaderer, Andrew L.; Wang, Huanyu; Kim, SungHwan; Kline, Jennifer M.; Liang, Dong; Brophy, Pat D.; McHugh, Kirk M.; Tseng, George C.; Saxena, Vijay; Barr-Beare, Evan; ...
Open Access English
  • Published: 03 Mar 2016
  • Publisher: American Society of Nephrology
Abstract
The contribution of genetic variation to urinary tract infection (UTI) risk in children with vesicoureteral reflux is largely unknown. The innate immune system, which includes antimicrobial peptides, such as the α-defensins, encoded by DEFA1A3, is important in preventing UTIs but has not been investigated in the vesicoureteral reflux population. We used quantitative real–time PCR to determine DEFA1A3 DNA copy numbers in 298 individuals with confirmed UTIs and vesicoureteral reflux from the Randomized Intervention for Children with Vesicoureteral Reflux (RIVUR) Study and 295 controls, and we correlated copy numbers with outcomes. Outcomes studied included reflux ...
Subjects
Medical Subject Headings: urologic and male genital diseasesfemale genital diseases and pregnancy complications
free text keywords: Clinical Research, Nephrology, General Medicine, Placebo, Medicine, business.industry, business, Reflux, Antibiotics, medicine.drug_class, Odds ratio, Endocrinology, medicine.medical_specialty, Gastroenterology, Antibiotic prophylaxis, Bioinformatics, Urinary system, Vesicoureteral reflux, medicine.disease, Internal medicine, Population, education.field_of_study, education
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publication . Other literature type . Article . 2016

Polymorphisms in α-Defensin–Encoding DEFA1A3 Associate with Urinary Tract Infection Risk in Children with Vesicoureteral Reflux

Schwaderer, Andrew L.; Wang, Huanyu; Kim, SungHwan; Kline, Jennifer M.; Liang, Dong; Brophy, Pat D.; McHugh, Kirk M.; Tseng, George C.; Saxena, Vijay; Barr-Beare, Evan; ...