Polymorphisms in α-Defensin–Encoding DEFA1A3 Associate with Urinary Tract Infection Risk in Children with Vesicoureteral Reflux

Other literature type English OPEN
Schwaderer, Andrew L.; Wang, Huanyu; Kim, SungHwan; Kline, Jennifer M.; Liang, Dong; Brophy, Pat D.; McHugh, Kirk M.; Tseng, George C.; Saxena, Vijay; Barr-Beare, Evan; Pierce, Keith R.; Shaikh, Nader; Manak, J. Robert; Cohen, Daniel M.; Becknell, Brian; Spencer, John D.; Baker, Peter B.; Yu, Chack-Yung; Hains, David S.;
  • Publisher: American Society of Nephrology
  • Related identifiers: pmc: PMC5042661, doi: 10.1681/ASN.2015060700
  • Subject: Clinical Research
    mesheuropmc: urologic and male genital diseases | female genital diseases and pregnancy complications

The contribution of genetic variation to urinary tract infection (UTI) risk in children with vesicoureteral reflux is largely unknown. The innate immune system, which includes antimicrobial peptides, such as the α-defensins, encoded by DEFA1A3, is important in preventin... View more
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