publication . Article . Other literature type . 2018

Role of TRPA1 in acute cardiopulmonary toxicity of inhaled acrolein.

Conklin Daniel J.; Haberzettl Petra; Jagatheesan Ganapathy; Kong Maiying; Hoyle Gary W.;
Open Access
  • Published: 13 Nov 2018 Journal: Toxicology and Applied Pharmacology, volume 324, pages 61-72 (issn: 0041-008X, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Abstract Acrolein is a highly toxic, volatile, unsaturated aldehyde generated during incomplete combustion as in tobacco smoke and indoor fires. Because the transient receptor potential ankyrin 1 (TRPA1) channel mediates tobacco smoke-induced lung injury, we assessed its role in high-level acrolein-induced toxicity in mice. Acrolein (100–275 ppm, 10–30 min) caused upper airway epithelial sloughing, bradypnea and oral gasping, hypothermia, cardiac depression and mortality. Male wild-type mice (WT, C57BL/6; 5–52 weeks) were significantly more sensitive to high-level acrolein than age-matched, female WT mice. Both male and female TRPA1-null mice were more sensitive...
Subjects
Medical Subject Headings: psychological phenomena and processesfood and beverages
free text keywords: Toxicology, Pharmacology, Toxicity, Hypothermia, medicine.symptom, medicine, Inhalation exposure, Lung injury, Lung, medicine.anatomical_structure, Acrolein, chemistry.chemical_compound, chemistry, Bradypnea, Endocrinology, medicine.medical_specialty, Respiratory system, Internal medicine, Article
Related Organizations
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Article . Other literature type . 2018

Role of TRPA1 in acute cardiopulmonary toxicity of inhaled acrolein.

Conklin Daniel J.; Haberzettl Petra; Jagatheesan Ganapathy; Kong Maiying; Hoyle Gary W.;