Using genotype array data to compare multi- and single-sample variant calls and improve variant call sets from deep coverage whole-genome sequencing data

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Shringarpure, Suyash S.; Mathias, Rasika A.; Hernandez, Ryan D.; O’Connor, Timothy D.; Szpiech, Zachary A.; Torres, Raul; De La Vega, Francisco M.; Bustamante, Carlos D.; Barnes, Kathleen C.; Taub, Margaret A.;
(2016)

Abstract Motivation: Variant calling from next-generation sequencing (NGS) data is susceptible to false positive calls due to sequencing, mapping and other errors. To better distinguish true from false positive calls, we present a method that uses genotype array data fr... View more
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