publication . Article . Other literature type . 2008

Cell polarity proteins: common targets for tumorigenic human viruses.

Javier, RT;
Open Access
  • Published: 24 Nov 2008 Journal: Oncogene, volume 27, pages 7,031-7,046 (issn: 0950-9232, eissn: 1476-5594, Copyright policy)
  • Publisher: Springer Science and Business Media LLC
Abstract
Loss of polarity and disruption of cell junctions are common features of epithelial-derived cancer cells, and mounting evidence indicates that such defects have a direct function in the pathology of cancer. Supporting this idea, results with several different human tumor viruses indicate that their oncogenic potential depends in part on a common ability to inactivate key cell polarity proteins. For example, adenovirus (Ad) type 9 is unique among human Ads by causing exclusively estrogen-dependent mammary tumors in experimental animals and in having E4 region-encoded open reading frame 1 (E4-ORF1) as its primary oncogenic determinant. The 125-residue E4-ORF1 prot...
Subjects
free text keywords: Genetics, Cancer Research, Molecular Biology, PDZ domain, Cell polarity, Plasma protein binding, Membrane protein, Cancer cell, Carcinogenesis, medicine.disease_cause, medicine, DLG1, biology.protein, biology, Cell junction, Article
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Other literature type . 2008
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publication . Article . Other literature type . 2008

Cell polarity proteins: common targets for tumorigenic human viruses.

Javier, RT;