publication . Other literature type . 2018

Production of MPT-64 recombinant protein from virulent strain of Mycobacterium bovis

Mohammadi Tashakkori, M.; Tabatabaei, M.; Tebianian, M.; Mosavari, N.;
Open Access English
  • Published: 01 Jan 2018
  • Publisher: School of Veterinary Medicine, University of Shiraz
Tuberculosis (TB) is a zoonotic infectious disease common to humans and animals which has been caused by a rod shaped, acid fast bacterium, called Mycobacterium bovis. The rapid and sensitive detection is a great challenge for TB diagnosis. The virulent strains of Mycobacterium tuberculosis complex (MTBC) have 16 different regions of difference (RD) in their genome which encode some important antigens. The major protein of M. bovis 64 (MPT-64) is one of the main immune-stimulating antigens which are encode by RD-2 region. The aim of the present study was cloning, expression and purification of MPT-64 as a protein antigen of M. bovis in a prokaryotic system for t...
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Other literature type . 2018
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