Flavaglines target primitive leukemia cells and enhance anti-leukemia drug activity

Other literature type English OPEN
Callahan, Kevin P.; Minhajuddin, Mohammad; Corbett, Cheryl; Lagadinou, Eleni D.; Rossi, Randall M.; Grose, Valerie; Balys, Marlene M.; Pan, Li; Jacob, Steven; Frontier, Alison; Grever, Michael R.; Lucas, David M.; Kinghorn, A. Douglas; Liesveld, Jane L.; Becker, Michael W.; Jordan, Craig T.;

Identification of agents that target human leukemia stem cells (LSCs) is an important consideration for the development of new therapies. The present study demonstrates that rocaglamide and silvestrol, closely related natural products from the flavagline class of compou... View more
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