High PD-L1/CD86 MFI ratio and IL-10 secretion characterize human regulatory dendritic cells generated for clinical testing in organ transplantation

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Zahorchak, Alan F.; Macedo, Camila; Hamm, David E.; Butterfield, Lisa H.; Metes, Diana M.; Thomson, Angus W.;

Human regulatory dendritic cells (DCreg) were generated from CD14 immunobead-purified or elutriated monocytes in the presence of vitamin D3 and IL-10. They exhibited similar, low levels of costimulatory CD80 and CD86, but comparatively high levels of co-inhibitory progr... View more
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