publication . Article . 2017

Electronic Cigarettes Show No Cell Transformation Activity

Breheny, Damien; Oke, Oluwatobiloba; Pant, Kamala; Gaça, Marianna; Umbezeiro, G.;
Open Access
  • Published: 26 Apr 2017 Journal: Environmental and Molecular Mutagenesis, volume 58, pages 190-198 (issn: 0893-6692, Copyright policy)
  • Publisher: Wiley
Abstract
In vitro cell transformation assays (CTA) are used to assess the carcinogenic potential of chemicals and complex mixtures and can detect nongenotoxic as well as genotoxic carcinogens. The Bhas 42 CTA has been developed with both initiation and promotion protocols to distinguish between these two carcinogen classes. Cigarette smoke is known to be carcinogenic and is positive in in vitro genotoxicity assays. Cigarette smoke also contains nongenotoxic carcinogens and is a tumour promoter and cocarcinogen in vivo. We have combined a suite of in vitro assays to compare the relative biological effects of new categories of tobacco and nicotine products with traditional...
Subjects
free text keywords: Genetics(clinical), Epidemiology, Health, Toxicology and Mutagenesis, Molecular biology, Nicotine, medicine.drug, medicine, Pharmacology, Biology, Carcinogen, Tobacco smoke, In vitro toxicology, Mutagen, medicine.disease_cause, Cocarcinogen, Genotoxicity, Electronic cigarette, law.invention, law, Toxicology, Research Article, Research Articles, e‐cigarettes, in vitro, carcinogenesis, risk assessment, nongenotoxic
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publication . Article . 2017

Electronic Cigarettes Show No Cell Transformation Activity

Breheny, Damien; Oke, Oluwatobiloba; Pant, Kamala; Gaça, Marianna; Umbezeiro, G.;