publication . Article . Other literature type . 1994

5-Hydroxytryptamine and human small intestinal motility: effect of inhibiting 5-hydroxytryptamine reuptake.

Gorard, D A; Libby, G W; Farthing, M J;
Open Access
  • Published: 01 Apr 1994 Journal: Gut, volume 35, pages 496-500 (issn: 0017-5749, Copyright policy)
  • Publisher: BMJ
Abstract
Parenteral 5-hydroxytryptamine stimulates small intestinal motility, but the effect of continuous stimulation with 5-hydroxytryptamine on the human migrating motor complex is unknown. Using a selective 5-hydroxytryptamine reuptake inhibitor, paroxetine, this study investigated the effect of indirect 5-hydroxytryptamine agonism on fasting small intestinal motility and transit. Eight healthy subjects were studied while receiving paroxetine 30 mg daily for five days and while receiving no treatment, in random order. Ambulant small intestinal motility was recorded from five sensors positioned from the duodenojejunal flexure to the ileum for 16-18 hours. Paroxetine r...
Subjects
free text keywords: Gastroenterology, Lactulose, medicine.drug, medicine, Small intestine, medicine.anatomical_structure, Ileum, Jejunum, Migrating motor complex, Endocrinology, medicine.medical_specialty, Paroxetine, Reuptake inhibitor, Reuptake, business.industry, business, Internal medicine, Research Article
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publication . Article . Other literature type . 1994

5-Hydroxytryptamine and human small intestinal motility: effect of inhibiting 5-hydroxytryptamine reuptake.

Gorard, D A; Libby, G W; Farthing, M J;