Co-Stimulation Blockade Inhibits Allergic Sensitization but does not Affect Established Allergy in a Murine Model of Grass Pollen Allergy1

Other literature type English OPEN
Linhart, Birgit; Bigenzahn, Sinda; Hartl, Arnulf; Lupinek, Christian; Thalhamer, Josef; Valenta, Rudolf; Wekerle, Thomas;

Type I allergy is characterized by the development of an initial Th2-dependent allergen-specific IgE response, which is boosted upon subsequent allergen encounter. While the immediate symptoms of allergy are mainly IgE-mediated, allergen-specific T cell responses contri... View more
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