publication . Article . 1964

GAMMA GLOBULIN METABOLISM IN RABBITS DURING THE ANAMNESTIC RESPONSE

Evangelos A. Catsoulis; Edward C. Franklin; Murray Oratz; Marcus A. Rothschild;
Open Access English
  • Published: 01 Apr 1964 Journal: The Journal of Experimental Medicine, volume 119, issue 4, pages 615-631 (issn: 0022-1007, eissn: 1540-9538, Copyright policy)
  • Publisher: The Rockefeller University Press
Abstract
<jats:p>1. Gamma globulin metabolism and distribution were studied employing rabbit gamma globulin (RGG)I131 24 times in 13 control rabbits. Similar studies were performed before and during the ananmestic response in 4 rabbits previously sensitized with a polyvalent pneumococcal vaccine.</jats:p> <jats:p>2. During the ananmestic response, gamma-globulin levels increased from 1.0 to 6.0 gm/100 ml, and the gamma-globulin pool increased from 0.7 to 4.7 gm/kg. There was no change in the intravascular-extravascular partition of gamma globulin.</jats:p> <jats:p>3. Gamma globulin degradation increased from 0.06 to 0.33 gm/kg/day during the 28 days of the immunization p...
Subjects
free text keywords: Article, Immunology, Immunology and Allergy, Immunologic memory, Gamma globulin, Antigen-antibody reactions, Polyvalent pneumococcal vaccine, Metabolism, Anamnestic response, Biology
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publication . Article . 1964

GAMMA GLOBULIN METABOLISM IN RABBITS DURING THE ANAMNESTIC RESPONSE

Evangelos A. Catsoulis; Edward C. Franklin; Murray Oratz; Marcus A. Rothschild;